HGH (somatotropin) in Thailand
secretion of growth hormone is greatly increased. Then grow giants, which sometimes reach a height of more than 2 m. This condition is considered a disease and it’s called "gigantism." Many people on our planet, however, would be very pleased to become not giants, but just high people. Many Parents want to increase the growth of their children, and now it is already possible.
By the way, the tallest man ever lived on Earth, had an increase of 2 m 48 cm (!). Sometimes the secretion of growth hormone increases dramatically already in the adult body, when most of the growth zones are already closed. In this case, the person's lower jaw, nose, hands and feet are significantly grown. This condition is called acromegaly, i.e. increase in peripheral parts of the body. In an adult and fully formed body, somatotropin performs anabolic functions.
It is responsible for the processes of protein synthesis in all organs and tissues without exception. Few people know that HGH plus everything is also a stress hormone. Under stress, the blood glucose level in the blood rises sharply, and this helps the body to adapt to the unfavorable situation by increasing protein synthesis, primarily in the energy structures of the cell.
Therefore, people of strong constitution with a good strong skeleton in general are better tolerated by all sorts of stresses and vicissitudes of our lives. They are helped in this by somatotropin. Since the growth zones of the lower jaw, nose, hands and feet are never closed, these "parts" grow throughout life. But even at old age they grow a little, on average by 5-8 mm.
There are, however, and their exceptions, a person at retirement age, the nose and fists reach a rather impressive size, which serves as a constant subject for jokes around. Large-scale studies in Thailand have shown that after the completion of growth at a young age, the person during the subsequent life still slightly "grows up." But this growth is very little. By the age of 60, a man grows 8-10 mm long and about the same width.
This growth, however, is invisible due to stooping and weakening of the muscles, which come to this age in most people. With a lack of growth hormone in childhood, people grow very small, and they are called dwarfs. In the language of physicians, this condition is called "hypophysial nanism." In the presence of a deficit of growth hormone in an adult of normal growth, various types of dystrophy develop, which sometimes even end in death, but they are extremely rare. In itself, the name "hypophysial nanism" already suggests that somatotropin is produced in the pituitary gland.
What is the pituitary gland now knows all or almost all. The pituitary gland is the lower cerebral appendage, the outgrowth on the base of the brain. The shape and size of the pituitary gland resembles cherry. The pituitary gland is well protected in the strength of its mild vulnerability.
It is located in a strong bone case - the "Turkish saddle" on the base of the skull. In the pituitary gland other hormones are produced - thyroid-stimulating hormone (affecting the thyroid gland), adreno corticotropic (activates the adrenal glands), gonadotropic (activates the sex glands), and others.
The work of the pituitary is regulated by the hypothalamus, a special area of the midbrain. There, liberins and statins are being developed. For somatotropic hormone, somatoliberin and somatostatin are important. Somatoliberin hypothalamus increases the secretion ofgrowth hormone by the pituitary gland. Somatostatin, on the contrary, inhibits the production of somatotropin. If we want to increase the amount of growth hormone in the body, then it is necessary either to increase the amount of somatoliberin, or to reduce the amount of somatostatin.
For a long time it was believed that the growth hormone is capable of itself acting on muscle tissue, cartilage and internal organs. Subsequently it turned out that this is not so. HGH is able to affect cells only in vitro in concentrations of 2,000 times higher than physiological. In a normal body, the HGH acts solely on the liver.
The liver produces an insulin-like growth factor, which is also called somatomedin. Somatomedin - also has an anabolic and growth effect, affecting the target cells. As a clinician, I often see cases when after a severe liver disease the child stops growing and a similar condition to pituitary nanism occurs, although the disease as such is caused by a lack of somatomedine.
On the other hand, acromegaly is common with normal levels of glucose in the blood. The disease in this case is caused by an excessive level of somatomedine in the blood. In general, the chain of regulation of anabolism with somatotropic hormone applied to skeletal muscles is as follows:
and start this treatment with somatotropin.After all, in the historical aspect, it all began with it. STG is a peptide hormone. It consists of a sufficiently long chain amino acid comprising 191 amino acid residues. As early as 1921, physiologists in experiments on animals evoked experimental gigantism when they introduced a crude extract of the anterior lobe of bovine pituitary glands. As we can see, the possibility of increasing the growth of a young organism has been proved for a long time already.
Purified somatotropin of animal origin was first isolated in 1944, uman - in 1956. Even then, with the help of STH, dwarfs with consistently good results began to be treated with might and main. Subsequently, it was found that there are at least three forms of STH with different molecular weights. In humans, STH is produced in the so-called eosinophilic cells of the pituitary gland.
In tumors of eosinophilic cells, as a rule, those instances of gigantism develop when human growth is much greater than 2 m. At this stage of development of medicine, such tumors are successfully treated both medically and operatively. High growth, however, remains. Among the world-class basketball players, there are many people who underwent pituitary surgery in their young years.
The tumor is removed through the nose (!), And the person lives, as if nothing had happened. There are, however, inoperable cases. On the other hand, the number of artificially "grown" players is growing, which at a young age was injected with growth hormone to increase growth.
The secretion of growth hormone into the blood is pulsed. During the day there are, as a rule, 6-9 large peaks. The number of such peaks sometimes reaches 12. The height of the peaks increases with physical activity and during sleep. At meals, the height of the peaks of the release of somatotropin, on the contrary, decreases, especially if this food is carbohydrate.
The STG of all mammals has the same biologically active nucleus. Phylogenetic lower animal species react to higher GHGs, but STG of lower species do not act on higher species. Human STG, for example, acts on all kinds of animals, but none of the somatotropin animals per person acts.
STG monkeys will act on increasingly less advanced animal species, but not on humans. The STG of the whale will again act on animals of a lower organization, but not only on a human or monkey, etc.